Hemophilia

• A, common, VIII
• B, less common, IX
• Assume 0% activity
• Use wt based replacement
• Minor, Moderate or severe bleed – target %
• Factor VIII 2% per unit/kg
• Factor IX 1% per unit/kg
• If no factor – can use FFP, Cryo, DDAVP (for VIII)

Von Willebrand’s Disease

• Most common bleeding dyscrasia
• Causes platelet dysfunction
• Mucosal bleeding, menorrhagia
• Tx = DDAVP 20 mcg IV (release VWB from endothelium) + consider TXA